Denosyl is available enteric-coated tablets for cats and dogs.
Licensed U.S. Pet Pharmacy | Verified Pharmacy
Sitewide SALE! GET 15% Off! Use Code EPX15 *
Denosyl
Item#
FREE SHIPPING Over $79! * Pet Food & Other Exclusions
1. Select pet size:
2. Select count:
$23.99Reg $31.99
$71.97Reg $93.99
$31.99Reg $41.99
$95.97Reg $124.99
$54.99Reg $71.99
- Notice
- Description
- Ingredients
- Directions
- FAQ
- Reviews
Notices
Due to current limited supply, we are only shipping 3 per customer until Denosyl becomes more available.
Description
Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. It's main ingredient is S-Adenosylmethionine (SAMe).
Key Benefits:
- Denosyl is formulated for liver and brain health
- Increases levels of glutathione, an important compound for liver health
- Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
- Increases cerebrospinal fluid in the brain that pets lose as they age
- Easy to administer tablets for medium dogs
How It Works
Denosyl has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5
While best known for supporting the liver in dogs and cats, research has shown that the SAMe in Denosyl may help support cognitive function in dogs.6 Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.7-9
References
- Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
- Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
- Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
- McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
- Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
- Rème CA, Dramard V, Kern L, et al. Vet Therap 2008;9(2):69-82.
- Tchantchou F, Graves M, Ortiz D, et al. J Nutr Health Aging 2006;10(6):541–544.
- Tchantchou F, Graves M, Falcone D, Shea TB. J Alzheimers Dis 2008;14:323–328.
- Shea TB, Chan A. J Alzheimers Dis 2008;13:67–70.
- Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
- Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.
Ingredients
S-Adenosylmethionine
Directions
Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.
For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.10,11 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.
Denosyl Canine and Feline Daily* Administration Guide
| For Cats (90 mg) | ||
|---|---|---|
| Body Weight | Body Weight | Number of Tablets Per Day |
| Up to 12 lbs | Up to 5.5 kg | 1 tablet |
| Over 12 lbs | Over 5.5 kg | 2 tablets |
| For Small Dogs (90 mg) | ||
| Body Weight | Body Weight | Number of Tablets Per Day |
| Up to 12 lbs | Up to 5.5 kg | 1 tablet |
| For Medium Dogs (225 mg) | ||
| Body Weight | Body Weight | Number of Tablets Per Day |
| 13 - 34 lbs | 6 - 15.5 kg | 1 tablet |
| For Large Dogs (425 mg) | ||
| Body Weight | Body Weight | Number of Tablets Per Day |
| 35 - 65 lbs | 16 - 29.5 kg | 1 tablet |
| 66 - 120 lbs | 30 - 54.5 kg | 2 tablets |
| Over 120 lbs | Over 54.5 kg | 3 tablets |
The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.
Many pets are maintained long-term on every-other-day or every-third-day administration.
Storage:
Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.
FAQ
The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.
Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.
Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their pet’s appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your pet’s liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.
Like all medicines, Revolt has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs.
If you have additional questions about possible side effects, talk to your veterinarian.
In well-controlled clinical studies, selamectin was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.
Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolt. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's or cat's medicines can be given together.
Revolt is flammable - Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.